Kidney failure, a condition where one or both kidneys no longer function properly, can lead to a range of symptoms. These can include fatigue, swelling (edema), changes in urination, nausea and vomiting, and in some cases, muscle cramps. Other symptoms may include loss of appetite, itching, shortness of breath, and trouble concentrating. Here's a more detailed look at some common symptoms: Changes in Urine Output and Quality: